Biological Sciences : Vaccines Molecular Target to Diagnose & Treat Pancreatic Cancer & Methods to Identify New Targets (JHU ref. C10569) BACKGROUND Pancreatic cancer is a malignant tumor of the pancreas. Each year ~250,000 people worldwide ... More...   Chlamydia vaccine (JHU ref. C09816) According to the World Health Organization, approximately 92 million new cases of Chlamydia trachomatis ... More...   FDA approved drug enhances the DNA vaccine potency to control HPV-associated malignancies (JHU ref. C10371) The majority (98%) of all cervical cancers are the result of human papillomavirus infection (HPV). According ... More...   Monoclonal antibodies in combination with DNA vaccine enhance therapeutic anti-tumor effects (JHU ref. C10372) Human papillomavirus (HPV) infection causes 98% of all cervical cancers. About 20 million Americans ... More...   Low-dose radiation enhances therapeutic HPV DNA vaccination (JHU ref. C10373) Human papillomavirus (HPV) infection causes 98% of all cervical cancers. About 20 million Americans ... More...   The most effective method of HPV DNA vaccine administration (JHU ref. C10597) One of the methods to protect an organism against the diseases is DNA vaccination, where genetically ... More...   Immunoliposomal Delivery of Vaccine to the Spleen (JHU ref. C10277) A fundamental problem in all vaccination methods is to present the target antigen to the appropriate ... More...   Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants (JHU ref. C04630) Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize ... More...   Stat3 Antagonists and Their Uses as Vaccines Against Cancer (JHU ref. C04271) The present invention relates to methods for treating and/or preventing cancer. In particular the present ... More...   Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination (JHU ref. C10228) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly ... More...   Generation and Characterization of a Preventive and Therapeutic HPV DNA Vaccine (JHU ref. 10014) Cervical cancer is one of the most common cancers in women worldwide. Persistent infection with human ... More...   Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency (JHU ref. 10012) Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties ... More...   Formulation of Toll-like Receptor Ligand With Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses (JHU ref. 5152) Established reports in literature have shown that the innate immune system can modulate immune responses ... More...   Multitypic Recombinant Adenovirus Vaccines against HPV and Malaria (JHU ref. C05017) JHU scientists have developed vaccines against human papillomavirus (HPV) infection and malaria, consisting ... More...   Mycobacterial Catalase-peroxidase in the Diagnosis and Treatment of Sarcoidosis (JHU ref. 4915) Sarcoidosis is an organ-wide inflammatory disease of unknown etiology that is characterized by the presence ... More...   Development of a DNA vaccine targeting HPV-16 oncoprotein E6 (JHU ref. 4450) Human papillomavirus (HPV), particularly type-16, is present in over 99% of cervical cancers. The HPV ... More...   Cancer Immunotherapy Using a DNA Vaccine Encoding a Single-Chain Trimer of MHC class I Linked to an HPV-16 E6 Immunodominant CTL Epitope (JHU ref. 4451) The potency of DNA vaccines may be affected by the efficiency of intracellular processing and MHC class ... More...   Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants (JHU ref. 4630) Vaccines for diverse viruses will be most effective when they direct the recipient’s response to recognize ... More...   Modification of Professional Antigen-Presenting Cells with Small Interfering RNA (siRNA) Targeting BAK and/or BAX Can Enhance DNA Vaccine Potency  (JHU ref. 4464)        It is now clear that dendritic cells (DCs) are the most potent professional antigen presenting ... More...   Characterization of DNA Vaccines Encoding the Domains of Calreticulin for Their Ability to Elicit Tumor-Specific Immunity and Anti- angiogenesis  (JHU ref. 4595) JHU scientists previously developed a DNA vaccine encoding calreticulin (CRT) linked to human papillomavirus-16 ... More...   Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies. (JHU ref. 4573) Human papillomavirus E6 and E7 are consistently expressed and responsible for the HPV associated malignancy ... More...   A Combination of DNA Vaccines Targeting Human Papillomavirus Type 16 E6 and E7 Generates Potent Antitumor Effects  (JHU ref. 4572) Human papillomavirus (HPV) infects large numbers of women in the world and is present in more than 99% ... More...   Antitumor Effects Generated by pNGVL4a-Sig/E7 (detox)/HSP70 DNA Vaccine Administered Through Gene Gun, Biojector and Syringe  (JHU ref. 4221) DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have ... More...   Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies  (JHU ref. 4178) Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant ... More...   Mesothelin is an Immunogenic target for Vaccination and Immune Monitoring in Pancreatic Cancer and Other Cancers (JHU ref. 4083) This invention describes a novel immunogenomic approach to the discovery of cancer antigens that are ... More...   Enhancing DNA Potency By Co-administration of DNA Encoding Anti-apoptotic Proteins (JHU ref. 3978) Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of ... More...   Enhancement of DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen (JHU ref. 3895) We have previously employed an intercellular spreading strategy using herpes simplex virus type 1 (HSV-1) ... More...   DNA Vaccine Plasmids Incorporating an Endosomal Trafficking signal as a Means to Access the MHC II Compartment of Antigen Presenting Cells (JHU ref. 3865) Johns Hopkins University researchers have synthesized DNA chimera vaccines consisting of antigenic sequences ... More...   DNA Vaccines as a Chimera Composed of the Antigen Gene Inserted in the Luminal Domain of the Lysosome-Associated Membrane Protein (LAMP) (JHU ref. 3864) Johns Hopkins University researchers have developed novel vaccine technology involving the fusion of ... More...   Recombinant Protein Chimera-mediated Expression of HIV-1 Gag Protein (JHU ref. 3834) The expression of the HIV-1 gene is tightly regulated at many levels when it is introduced into mammalian ... More...   Enhancement of Suicidal DNA Vaccine Potency by Linkage Mycobacterium Tuberculosis Heat Shock Protein 70 to an Antigen (JHU ref. 3797) Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because ... More...   Cancer Immunotherapy using a DNA Vaccine Encoding the Translocation Domain of a Bacterial Toxin Linked to a Tumor Antigen (JHU ref. 3794) DNA vaccines are an attractive approach for tumor immunotherapy. One concern about DNA vaccines is their ... More...   Enhancement of Nucleic Acid Vaccine Potency by Intercellular Spreading and Enhancement of MHC Class I Presentation of Antigen Linked to Herpesvirus VP22 Protein (JHU ref. 3719) The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, ... More...   Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium Tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene (JHU ref. 3693) Self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid ... More...   Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to the Extracellular Domain of FLT3-Ligand Gene (JHU ref. 3668) Flt3 (fms-like tyrosine kinase 3)-ligand has been identified as an important cytokine for the generation ... More...   Fusion of Calreticulun (CRT) to Antigens Enhances the Potency of DNA Vaccines (JHU ref. 3661) Antigen-specific cancer immunotherapy and anti-angiogenesis have emerged as two attractive strategies ... More...   Novel Strategy to Enhance the DNA Vaccine Potency (JHU ref. 3620) Nucleic acid vaccines represent an attractive approach to generating antigen-specific immunity because ... More...   Biodegradable, timed release cytokine depots: A new approach in cancer vaccine design (JHU ref. 9733) Experimental studies have demonstrated that potent systemic immunity can be generated using tumor vaccines ... More...   A Clone Partially Encoding A 200-kDa Glycoprotein of Schistosoma mansoni Schistosomula (JHU ref. 9156) Polypeptide epitopes are defined herein which when used as components of vaccine compositions, induced ... More...             Home | Legal | Site Credits